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  • Thymic output: influence factors and molecular mechanism
  • Jin R; Zhang J; Chen W
  • Cell Mol Immunol 2006[Oct]; 3 (5): 341-50
  • Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate (S1P), transcription factors such as Foxj1, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc. In this review, we summarized the recent reports about study strategies, influence factors and possible molecular mechanisms in thymic output.
  • |Animals[MESH]
  • |Humans[MESH]
  • |T-Lymphocytes/cytology/*immunology[MESH]
  • |Thymus Gland/cytology/*immunology/metabolism[MESH]

  • *{{pmid17092431}}
    *<b>[ Thymic output: influence factors and molecular mechanism ]</b> Cell Mol Immunol 2006; 3(5) ; 341-50 Jin R; Zhang J; Chen W


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    Cell Mol Immunol

    341 5.3 2006