Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Control of fatty acid desaturation: a mechanism conserved from bacteria to humans Aguilar PS; de Mendoza DMol Microbiol 2006[Dec]; 62 (6): 1507-14Unsaturated fatty acids (UFAs) have profound effects on the fluidity and function of biological membranes. Microorganisms, plants and animals regulate the synthesis of UFAs during changing environmental conditions as well as in response to nutrients. UFAs homeostasis in many organisms is achieved by feedback regulation of fatty acid desaturase gene transcription through signalling pathways that are governed by sensors embedded in cellular membranes. Here, we review recently discovered components of the regulatory machinery governing the transcription of fatty acid desaturases in bacteria, yeasts and animals that indicate an ancient role of transmembrane signalling mechanisms and integrate membrane composition with lipid biosynthesis.|Bacteria/enzymology/genetics/*metabolism[MESH]|Fatty Acid Desaturases/genetics/*metabolism[MESH]|Fatty Acids, Unsaturated/*metabolism[MESH]|Fatty Acids/*metabolism[MESH]|Gene Expression Regulation, Enzymologic[MESH]|Humans[MESH]|Lipid Metabolism[MESH]|Models, Biological[MESH]|Signal Transduction[MESH] |