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lüll Catenins: keeping cells from getting their signals crossed Perez-Moreno M; Fuchs EDev Cell 2006[Nov]; 11 (5): 601-12Adherens junctions have been traditionally viewed as building blocks of tissue architecture. The foundations for this view began to change with the discovery that a central component of AJs, beta-catenin, can also function as a transcriptional cofactor in Wnt signaling. In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin. Catenins have emerged as molecular sensors that integrate cell-cell junctions and cytoskeletal dynamics with signaling pathways that govern morphogenesis, tissue homeostasis, and even intercellular communication between different cell types within a tissue. These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer.|Actins/metabolism[MESH]|Adherens Junctions/*physiology[MESH]|Animals[MESH]|Catenins[MESH]|Cell Adhesion Molecules/*physiology[MESH]|Cell Communication/*physiology[MESH]|Cell Cycle/physiology[MESH]|Cytoskeleton/physiology[MESH]|Delta Catenin[MESH]|Inflammation/pathology[MESH]|Neoplasms/pathology[MESH]|Phosphoproteins/*physiology[MESH]|Signal Transduction/physiology[MESH]|Wound Healing/physiology[MESH]|alpha Catenin/*physiology[MESH]|beta Catenin/*physiology[MESH] |