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Nucleic acid-sensing TLRs as modifiers of autoimmunity Deane JA; Bolland SJ Immunol 2006[Nov]; 177 (10): 6573-8The immune system requires precise regulation of activating and inhibitory signals so that it can mount effective responses against pathogens while ensuring tolerance to self-components. Some of the most potent activation signals are triggered by innate immune molecules, particularly those in the TLR family. Recent studies have shown that engagement of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on the ways that TLR function might contribute to the etiology of lupus-like syndromes in the context of an autoimmune-prone environment. By considering the sources, localization, and expression of both nucleic acids and the molecules that bind them, we discuss several ways that innate immunity can play a role in the development of systemic autoimmunity.|Animals[MESH]|Autoimmune Diseases/*genetics/*immunology/metabolism[MESH]|DNA/*immunology/metabolism[MESH]|Humans[MESH]|Immunity, Innate/genetics[MESH]|RNA/*immunology/metabolism[MESH]|Toll-Like Receptors/genetics/metabolism/*physiology[MESH] |
