Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Lysyl oxidase mediates hypoxic control of metastasis Erler JT; Giaccia AJCancer Res 2006[Nov]; 66 (21): 10238-41Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.|*Cell Hypoxia[MESH]|Breast Neoplasms/*enzymology/pathology[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis/*pathology/prevention & control[MESH]|Protein-Lysine 6-Oxidase/antagonists & inhibitors/*physiology[MESH] |
