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Methods and protocols for prediction of immunogenic epitopes Tong JC; Tan TW; Ranganathan SBrief Bioinform 2007[Mar]; 8 (2): 96-108T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.|Algorithms[MESH]|Antigen-Antibody Complex/analysis/*immunology[MESH]|Binding Sites[MESH]|Epitope Mapping/*methods[MESH]|Epitopes, T-Lymphocyte/analysis/chemistry/*immunology[MESH]|HLA Antigens/analysis/chemistry/*immunology[MESH]|Peptides/analysis/*immunology[MESH]|Protein Binding[MESH]|Protein Interaction Mapping/*methods[MESH]|Sequence Analysis, Protein/*methods[MESH] |
