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lüll Malignant pleural mesothelioma: a comprehensive review Ismail-Khan R; Robinson LA; Williams CC Jr; Garrett CR; Bepler G; Simon GRCancer Control 2006[Oct]; 13 (4): 255-63BACKGROUND: The incidence of malignant mesothelioma continues to increase, but the disease remains difficult to detect early and treat effectively. METHODS: The authors review the pathogenesis, incidence, clinical presentation, diagnosis, pathology, and both standard and experimental treatments for mesothelioma. RESULTS: When possible, surgery (video-assisted thoracoscopy, pleurectomy/decortication, or extrapleural pneumonectomy) is utilized. Effects on underlying structures limit application of radiation therapy, but some systemic agents are beginning to enhance survival. CONCLUSIONS: The disease is expected to increase in incidence till 2020, so awareness of this entity as a possible diagnosis should be heightened. In patients with advanced disease, several newer antitumor agents are already showing a capability of extending survival so it is not unreasonable to expect further progress in this area.|Humans[MESH]|Incidence[MESH]|Magnetic Resonance Imaging[MESH]|Mesothelioma/*diagnosis/epidemiology/*therapy[MESH]|Neoplasm Staging[MESH]|Pleural Effusion, Malignant/diagnosis/etiology/therapy[MESH]|Pleural Neoplasms/complications/*diagnosis/epidemiology/*therapy[MESH]|Tomography, X-Ray Computed[MESH]|United States/epidemiology[MESH] |