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lüll Antenatal oligohydramnios of renal origin: long-term outcome Klaassen I; Neuhaus TJ; Mueller-Wiefel DE; Kemper MJNephrol Dial Transplant 2007[Feb]; 22 (2): 432-9BACKGROUND: Prognosis of fetuses with renal oligohydramnios (ROH) is often still regarded as poor. Neonatal complications and the long-term follow-up of fetuses with ROH in two pediatric centres are described. Method. 23 fetuses (16 males, 7 females) were included as patients. Primary diseases included congenital anomalies of the kidney and urinary tract (n = 16), autosomal recessive polycystic kidney disease (n = 4) and renal tubular dysgenesis (n = 3). The analysis includes retrospective chart review. RESULTS: Seven children died (30%), the majority (n = 4, 17%) within the neonatal period due to pulmonary hypoplasia and renal insufficiency. Fourteen patients (61%) required postnatal mechanical ventilation for a median of 4 (range 1-60) days; 11 infants had an associated pneumothorax. All 16 surviving children have chronic kidney disease (CKD) at a current median age of 5.7 years (range 0.5-14.5), managed conservatively in eight patients [median glomerular filtration rate 51 (range 20-78) ml/min/1.73 m(2)]. Eight patients reached end-stage renal disease at a median age of 0.3 years (range 2 days to 8.3 years), including one patient with pre-emptive kidney transplantation. Five of the patients requiring dialysis underwent successful renal transplantation at a median age of 3.5 years (range 2.5-4). Growth was impaired in seven children requiring growth hormone treatment. Cognitive and motor development was normal in 12 (75%) of the 16 patients and showed a delay in four children, including two with associated syndromal features. CONCLUSION: ROH is not always associated with a poor prognosis and long-term outcome in survivors is encouraging. The high incidence of neonatal complications and long-term morbidity due to CKD requires a multidisciplinary management of these children.|Adolescent[MESH]|Child[MESH]|Child, Preschool[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Incidence[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Kidney Diseases/*complications/congenital/embryology[MESH]|Male[MESH]|Oligohydramnios/diagnosis/epidemiology/*etiology[MESH]|Pregnancy[MESH]|Prenatal Diagnosis[MESH]|Prognosis[MESH]|Survival Rate[MESH]|Time Factors[MESH] |