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lüll Characterizing pathogenic processes in Batten disease: use of small eukaryotic model systems Phillips SN; Muzaffar N; Codlin S; Korey CA; Taschner PE; de Voer G; Mole SE; Pearce DABiochim Biophys Acta 2006[Oct]; 1762 (10): 906-19The neuronal ceroid lipofuscinoses (NCLs) are neurodegenerative disorders. Nevertheless, small model organisms, including those lacking a nervous system, have proven invaluable in the study of mechanisms that underlie the disease and in studying the functions of the conserved proteins associated to each disease. From the single-celled yeast, Saccharomyces cerevisiae and Schizosaccharomyces pombe, to the worm, Caenorhabditis elegans and the fruitfly, Drosophila melanogaster, biochemical and, in particular, genetic studies on these organisms have provided insight into the NCLs.|*Disease Models, Animal[MESH]|*Genetic Predisposition to Disease[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Caenorhabditis elegans/genetics[MESH]|Drosophila melanogaster/genetics[MESH]|Molecular Sequence Data[MESH]|Neuronal Ceroid-Lipofuscinoses/*genetics[MESH]|Saccharomyces cerevisiae/genetics[MESH]|Schizosaccharomyces/genetics[MESH]|Sequence Homology, Amino Acid[MESH] |