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lüll The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity Cancro MPAnn Rheum Dis 2006[Nov]; 65 Suppl 3 (Suppl 3): iii34-6The B lymphocyte stimulator (BLyS; also termed BAFF) family of ligands and receptors plays a central role in B lymphocyte development, selection, and homoeostasis. Members of this family can independently influence different B cell subsets, because the interactions between the two ligands and three receptors vary, and the receptors themselves are differentially expressed among developing, naive, and antigen experienced B cell subsets. These properties prompt careful assessment of how ablative therapies may influence the behaviour of upstream or downstream B lineage populations, as well as how the implementation and expectations of therapeutics targeting BLyS family members must be guided by knowledge of the B cell subsets contributing to pathogenesis.|Animals[MESH]|Autoimmune Diseases/*immunology/*therapy[MESH]|Autoimmunity[MESH]|B-Cell Activating Factor/*immunology[MESH]|B-Cell Activation Factor Receptor/immunology[MESH]|B-Lymphocytes/immunology[MESH]|Homeostasis/immunology[MESH]|Humans[MESH]|Ligands[MESH]|Lymphocyte Activation/immunology[MESH] |