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lüll Gene therapy of liver cancer Hernandez-Alcoceba R; Sangro B; Prieto JWorld J Gastroenterol 2006[Oct]; 12 (38): 6085-97The application of gene transfer technologies to the treatment of cancer has led to the development of new experimental approaches like gene directed enzyme/pro-drug therapy (GDEPT), inhibition of oncogenes and restoration of tumor-suppressor genes. In addition, gene therapy has a big impact on other fields like cancer immunotherapy, anti-angiogenic therapy and virotherapy. These strategies are being evaluated for the treatment of primary and metastatic liver cancer and some of them have reached clinical phases. We present a review on the basis and the actual status of gene therapy approaches applied to liver cancer.|Angiogenesis Inhibitors/therapeutic use[MESH]|Apoptosis/genetics[MESH]|Carcinoma, Hepatocellular/*therapy[MESH]|Gene Expression[MESH]|Gene Targeting[MESH]|Genes, Tumor Suppressor[MESH]|Genetic Therapy/*methods[MESH]|Humans[MESH]|Immunotherapy/methods[MESH]|Liver Neoplasms/*therapy[MESH]|Oncogenes[MESH]|Oncolytic Virotherapy/methods[MESH]|Prodrugs/therapeutic use[MESH] |