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lüll DNA nanomachines and nanostructures involving quadruplexes Alberti P; Bourdoncle A; Sacca B; Lacroix L; Mergny JLOrg Biomol Chem 2006[Sep]; 4 (18): 3383-91DNA is an attractive component for molecular recognition, because of its self-assembly properties. Its three-dimensional structure can differ markedly from the classical double helix. For example, DNA or RNA strands carrying guanine or cytosine stretches associate into four-stranded structures called G-quadruplexes or i-DNA, respectively. Since 2002, several groups have described nanomachines that take advantage of this structural polymorphism. We first introduce the unusual structures that are involved in these devices (i.e., i-DNA and G-quadruplexes) and then describe the opening and closing steps that allow cycling. A quadruplex-duplex molecular machine is then presented in detail, together with the rules that govern its formation, its opening/closing kinetics and the various technical and physico-chemical parameters that play a role in the efficiency of this device. Finally, we review the few examples of nanostructures that involve quadruplexes.|*Nucleic Acid Conformation[MESH]|Base Sequence[MESH]|DNA/*chemistry/genetics[MESH]|G-Quadruplexes[MESH]|Molecular Sequence Data[MESH]|Nanostructures/*chemistry[MESH] |