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Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas Sun XF; Zhang HMol Cancer 2006[Oct]; 5 (ä): 43Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various proteins, have also important impacts on tumour development and progression. It has been shown that disruption of stromal-epithelial interactions influences cellular proliferation, differentiation, death, motility, genomic integrity, angiogenesis, and other phenotypes in various tissues. Moreover, stromal variables are also critical to therapy in cancer patients. In this review, we mainly focus on the clinicopathological significance of stromal variables including angiogenesis, lymphangiogenesis, inflammatory infiltration, matrix metalloproteinase (MMP), and the particularly interesting new cysteine-histidine rich protein (PINCH) in colorectal cancer (CRC).|Adaptor Proteins, Signal Transducing[MESH]|Adenocarcinoma/drug therapy/*etiology/metabolism[MESH]|Colorectal Neoplasms/drug therapy/*etiology/metabolism[MESH]|DNA-Binding Proteins/metabolism/*physiology[MESH]|Enzyme Inhibitors/therapeutic use[MESH]|Humans[MESH]|Inflammation/*etiology/pathology[MESH]|LIM Domain Proteins[MESH]|Lymphangiogenesis/*physiology[MESH]|Matrix Metalloproteinase Inhibitors[MESH]|Matrix Metalloproteinases/metabolism/*physiology[MESH]|Membrane Proteins[MESH]|Models, Biological[MESH]|Neoplasm Invasiveness/pathology[MESH]|Neovascularization, Pathologic/*etiology[MESH]|Stromal Cells/pathology/*physiology[MESH] |
