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lüll Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses Rege TA; Hagood JSBiochim Biophys Acta 2006[Oct]; 1763 (10): 991-9Thy-1 is a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell activation, neurite outgrowth, apoptosis, tumor suppression, wound healing, and fibrosis. To mediate these diverse effects, Thy-1 participates in multiple signaling cascades. In this review, we discuss Thy-1 signaling primarily in non-immunologic cell types, including neurons, mesangial cells, ovarian cancer cells, nasopharyngeal carcinoma cells, endothelial cells, and fibroblasts. We review the current literature regarding Thy-1 signaling via integrins, protein tyrosine kinases, and cytokines and growth factors; and the roles of these signaling pathways in cellular adhesion, apoptosis, cell proliferation, and cell adhesion and migration. We also discuss the role of Thy-1 localization to lipid rafts, and of the GPI anchor in Thy-1 signaling. Ongoing research on the mechanisms of Thy-1 signaling will add to our understanding of the diverse physiologic and pathologic processes in which Thy-1 plays a role.|*Signal Transduction[MESH]|Animals[MESH]|Apoptosis[MESH]|Cell Adhesion[MESH]|Cell Proliferation[MESH]|Cell Survival[MESH]|Cells, Cultured[MESH]|Cytokines/*metabolism/physiology[MESH]|Integrins/metabolism/physiology[MESH]|Intercellular Signaling Peptides and Proteins/*metabolism/physiology[MESH]|Membrane Microdomains/metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Protein-Tyrosine Kinases/metabolism/physiology[MESH]|Thy-1 Antigens/genetics/*metabolism/*physiology[MESH] |