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Effect of verteporfin photodynamic therapy on endostatin and angiogenesis in human choroidal neovascular membranes Tatar O; Shinoda K; Adam A; Eckert T; Eckardt C; Lucke K; Deuter C; Bartz-Schmidt KU; Grisanti SBr J Ophthalmol 2007[Feb]; 91 (2): 166-73AIM: To evaluate the effect of verteporfin photodynamic therapy (PDT) on endostatin with regard to expression of vascular endothelial growth factor (VEGF) in human choroidal neovascular membranes (CNVs) secondary to age-related macular degeneration. METHODS: A retrospective review of an interventional case series of 68 patients who underwent removal of CNV. 29 patients were treated with PDT 3-655 days before surgery. 39 CNVs without previous treatment were used as controls. CNVs were stained for CD34, CD105, Ki-67, cytokeratin 18, endostatin, E-selectin and VEGF. "Predominance score of VEGF over endostatin" (mean) was defined as the difference between VEGF and endostatin staining scores. RESULTS: In four CNVs treated by PDT 3 days previously, PS was significantly higher in the retinal pigment epithelium (mean = 2.5, p = 0.006) and stroma (mean = 2, p = 0.015) than in the control group (mean = 0). At longer post-PDT intervals, PS was significantly decreased in the retinal pigment epithelium (mean = 0, p = 0.019) and stroma (mean = 0, p = 0.015). Proliferative activity was high (p = 0.023), but mostly related to inflammatory cells. PDT did not influence E-selectin expression significantly. CONCLUSIONS: VEGF predominance over endostatin early after PDT might contribute to enhanced angiogenic activity associated with recurrences. Strategies upregulating or replacing endostatin early after PDT might increase the effectiveness of PDT.|Aged[MESH]|Aged, 80 and over[MESH]|Choroidal Neovascularization/*drug therapy/etiology/*metabolism[MESH]|E-Selectin/metabolism[MESH]|Endostatins/*metabolism[MESH]|Female[MESH]|Humans[MESH]|Macular Degeneration/complications/drug therapy/metabolism[MESH]|Male[MESH]|Middle Aged[MESH]|Photochemotherapy/*methods[MESH]|Photosensitizing Agents/therapeutic use[MESH]|Pigment Epithelium of Eye/metabolism[MESH]|Porphyrins/therapeutic use[MESH]|Retrospective Studies[MESH]|Vascular Endothelial Growth Factor A/*metabolism[MESH]|Verteporfin[MESH] |
