Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
New techniques to understand chromosome dosage: mouse models of aneuploidy Tybulewicz VL; Fisher EMHum Mol Genet 2006[Oct]; 15 Spec No 2 (ä): R103-9Aberrations in human chromosome copy number and structure are common and extremely deleterious. Their downstream effects on phenotype are caused by aberrant dosage of sequences in the affected regions. However, we know little about why the abnormal gene copy number causes disease or why specific features result from deficits in specific chromosomes. Mice are the organism of choice to help us try to tease apart the complex relationships between genotype and phenotype in aneuploidy and segmental aneusomy syndromes. As new technologies such as chromosome engineering and the creation of transchromosomic mice become routine, these will help us identify individual dosage-sensitive genes that are causative in specific syndromes and will enable us to produce mouse models to accurately recapitulate human chromosomal disorders.|*Aneuploidy[MESH]|*Gene Dosage[MESH]|*Genetic Techniques[MESH]|Animals[MESH]|Female[MESH]|Gene Duplication[MESH]|Genetic Engineering[MESH]|Humans[MESH]|Male[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Models, Animal[MESH]|Models, Genetic[MESH]|Mosaicism[MESH]|Mutagenesis[MESH]|Phenotype[MESH] |
