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lüll Epigenetic effects of ethanol on liver and gastrointestinal injury Shukla SD; Aroor ARWorld J Gastroenterol 2006[Sep]; 12 (33): 5265-71Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential.|*Epigenesis, Genetic[MESH]|*Gene Expression Regulation[MESH]|Alcohol Drinking[MESH]|DNA Methylation[MESH]|Ethanol/*pharmacology[MESH]|Gastrointestinal Tract/*injuries[MESH]|Humans[MESH]|Liver Diseases, Alcoholic/genetics[MESH]|Liver/*injuries[MESH] |