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The role of heme oxygenase-1 in pulmonary disease Fredenburgh LE; Perrella MA; Mitsialis SAAm J Respir Cell Mol Biol 2007[Feb]; 36 (2): 158-65Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the antioxidant, antiapoptotic, antiproliferative, vasodilatory, and anti-inflammatory properties of HO-1. Although absence of HO-1 is rare in humans, a number of HO-1 promoter polymorphisms have been identified that may influence HO-1 expression in vivo and lead to disease states. This review will summarize studies that implicate HO-1 and heme metabolites in the pathophysiology of pulmonary disease and discuss recent advances in the therapeutic applications of HO-1.|Animals[MESH]|Genetic Predisposition to Disease[MESH]|Heme Oxygenase-1/genetics/*metabolism[MESH]|Humans[MESH]|Lung Diseases/*enzymology/genetics/therapy[MESH]|Polymorphism, Genetic[MESH]|Promoter Regions, Genetic/genetics[MESH]|Vascular Diseases/enzymology/genetics/therapy[MESH] |
