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Emerging roles of beta-arrestins Buchanan FG; DuBois RNCell Cycle 2006[Sep]; 5 (18): 2060-3Arrestins were originally characterized as structural adaptor proteins which modulate the desensitization and trafficking of seven-membrane-spanning receptors. From these seminal observations a multitude of novel functions for this gene family have arisen. Here we review the recently identified roles for beta-arrestin including its nuclear function and roles in development, cellular migration, and metastasis.|Animals[MESH]|Arrestins/genetics/*metabolism[MESH]|Cell Movement/physiology[MESH]|Cell Nucleus/*metabolism[MESH]|Humans[MESH]|Neoplasm Metastasis/genetics[MESH]|Protein Kinases/*metabolism[MESH]|Protein Transport/physiology[MESH]|Receptors, G-Protein-Coupled/*metabolism[MESH]|Signal Transduction/*physiology[MESH]|Wnt Proteins/metabolism[MESH]|beta-Arrestins[MESH] |
