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lüll Does the signal for the activation of T cells originate from the antigen-presenting cell or the effector T-helper?Cohn MCell Immunol 2006[May]; 241 (1): 1-6The present view is that the antigen-presenting cell (APC) processes and presents simultaneously on its surface several different antigens that are displayed randomly (with respect to their being Self or Nonself) as peptide-MHC complexes. The naive T-cell interacting with its ligand on the APC is activated by "co-stimulation," the first step on the pathway to effectors. This view ignores the requirement for associative recognition of antigen (ARA) in mediating both the Self-Nonself discrimination and the regulation of effector class. The introduction of ARA as a requirement for these two decision functions highlights a critical role for the effector T-helper (eTh) and necessitates rethinking the contribution of the APC.|Animals[MESH]|Antigen-Presenting Cells/*immunology/metabolism[MESH]|Humans[MESH]|Lymphocyte Activation/*immunology[MESH]|Signal Transduction/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH] |