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lüll The yeast actin cytoskeleton: from cellular function to biochemical mechanism Moseley JB; Goode BLMicrobiol Mol Biol Rev 2006[Sep]; 70 (3): 605-45All cells undergo rapid remodeling of their actin networks to regulate such critical processes as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven by the coordinated activities of a set of 20 to 30 highly conserved actin-associated proteins, in addition to many cell-specific actin-associated proteins and numerous upstream signaling molecules. The combined activities of these factors control with exquisite precision the spatial and temporal assembly of actin structures and ensure dynamic turnover of actin structures such that cells can rapidly alter their cytoskeletons in response to internal and external cues. One of the most exciting principles to emerge from the last decade of research on actin is that the assembly of architecturally diverse actin structures is governed by highly conserved machinery and mechanisms. With this realization, it has become apparent that pioneering efforts in budding yeast have contributed substantially to defining the universal mechanisms regulating actin dynamics in eukaryotes. In this review, we first describe the filamentous actin structures found in Saccharomyces cerevisiae (patches, cables, and rings) and their physiological functions, and then we discuss in detail the specific roles of actin-associated proteins and their biochemical mechanisms of action.|Actin Cytoskeleton/metabolism/physiology[MESH]|Actins/*metabolism/ultrastructure[MESH]|Cytokinesis/physiology[MESH]|Cytoskeleton/*metabolism/physiology/ultrastructure[MESH]|Fungal Proteins/metabolism/physiology[MESH]|Microfilament Proteins/metabolism/physiology[MESH]|Microscopy, Electron[MESH]|Models, Biological[MESH]|Saccharomyces cerevisiae/*metabolism/physiology/ultrastructure[MESH] |