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Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents Ambrus JL Sr; Chadha KC; Islam A; Akhter S; Ambrus JL JrExp Biol Med (Maywood) 2006[Sep]; 231 (8): 1283-6Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2'-deoxyoligocytidilates and telomerase inhibitors.|Animals[MESH]|Enzyme Inhibitors/pharmacology[MESH]|Humans[MESH]|Neoplasms/*therapy[MESH]|Poly I-C/therapeutic use[MESH]|RNA Interference/physiology[MESH]|RNA, Double-Stranded/*therapeutic use[MESH]|Telomerase/antagonists & inhibitors/drug effects[MESH]|Virus Diseases/*therapy[MESH] |
