Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis Kryczek I; Wei S; Keller E; Liu R; Zou WAm J Physiol Cell Physiol 2007[Mar]; 292 (3): C987-95The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and contributes to immunosuppressive networks within the tumor microenvironment. Therefore, it stands to reason that the CXCL12/CXCR4 pathway is an important target for the development of novel anti-cancer therapies. In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed.|Cell Transformation, Neoplastic/*metabolism/*pathology[MESH]|Chemokine CXCL12[MESH]|Chemokines, CXC/*metabolism[MESH]|Humans[MESH]|Neoplasms/blood supply/*metabolism/*pathology[MESH]|Neovascularization, Pathologic/*metabolism/*pathology[MESH]|Stromal Cells/metabolism/pathology[MESH]|Tumor Cells, Cultured[MESH] |