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lüll Plasticity of connections underlying locomotor recovery after central and/or peripheral lesions in the adult mammals Rossignol SPhilos Trans R Soc Lond B Biol Sci 2006[Sep]; 361 (1473): 1647-71This review discusses some aspects of plasticity of connections after spinal injury in adult animal models as a basis for functional recovery of locomotion. After reviewing some pitfalls that must be avoided when claiming functional recovery and the importance of a conceptual framework for the control of locomotion, locomotor recovery after spinal lesions, mainly in cats, is summarized. It is concluded that recovery is partly due to plastic changes within the existing spinal locomotor networks. Locomotor training appears to change the excitability of simple reflex pathways as well as more complex circuitry. The spinal cord possesses an intrinsic capacity to adapt to lesions of central tracts or peripheral nerves but, as a rule, adaptation to lesions entails changes at both spinal and supraspinal levels. A brief summary of the spinal capacity of the rat, mouse and human to express spinal locomotor patterns is given, indicating that the concepts derived mainly from work in the cat extend to other adult mammals. It is hoped that some of the issues presented will help to evaluate how plasticity of existing connections may combine with and potentiate treatments designed to promote regeneration to optimize remaining motor functions.|Aging/*physiology[MESH]|Animals[MESH]|Motor Activity/*physiology[MESH]|Neuronal Plasticity/*physiology[MESH]|Spinal Cord Injuries/*metabolism[MESH] |