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lüll Sit down, relax and unwind: structural insights into RecQ helicase mechanisms Killoran MP; Keck JLNucleic Acids Res 2006[]; 34 (15): 4098-105Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities.|Adenosine Triphosphatases/*chemistry/genetics/metabolism[MESH]|Adenosine Triphosphate/metabolism[MESH]|Bloom Syndrome/genetics[MESH]|DNA Helicases/*chemistry/genetics/metabolism[MESH]|DNA Replication/physiology[MESH]|Humans[MESH]|Hydrolysis[MESH]|Protein Structure, Tertiary/*physiology[MESH]|RecQ Helicases[MESH]|Rothmund-Thomson Syndrome/genetics[MESH]|Werner Syndrome/genetics[MESH] |