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lüll Evolving European guidance on the medical management of neovascular age related macular degeneration Chakravarthy U; Soubrane G; Bandello F; Chong V; Creuzot-Garcher C; Dimitrakos SA 2nd; Korobelnik JF; Larsen M; Mones J; Pauleikhoff D; Pournaras CJ; Staurenghi G; Virgili G; Wolf SBr J Ophthalmol 2006[Sep]; 90 (9): 1188-96BACKGROUND: Until recently, only two options were available for the treatment of choroidal neovascularisation (CNV) associated with age related macular degeneration (AMD)-thermal laser photocoagulation and photodynamic therapy with verteporfin (PDT-V). However, new treatments for CNV are in development, and data from phase III clinical trials of some of these pharmacological interventions are now available. In light of these new data, expert guidance is required to enable retina specialists with expertise in the management of AMD to select and use the most appropriate therapies for the treatment of neovascular AMD. METHODS: Consensus from a round table of European retina specialists was obtained based on best available scientific data. Data rated at evidence levels 1 and 2 were evaluated for laser photocoagulation, PDT-V, pegaptanib sodium, and ranibizumab. Other treatments discussed are anecortave acetate, triamcinolone acetonide, bevacizumab, rostaporfin (SnET2), squalamine, and transpupillary thermotherapy. RESULTS: PDT-V is currently recommended for subfoveal lesions with predominantly classic CNV, or with occult with no classic CNV with evidence of recent disease progression and a lesion size |Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/therapeutic use[MESH]|Aptamers, Nucleotide/therapeutic use[MESH]|Choroidal Neovascularization/*drug therapy/etiology/therapy[MESH]|Evidence-Based Medicine[MESH]|Humans[MESH]|Macular Degeneration/complications/*drug therapy/therapy[MESH]|Photochemotherapy/methods[MESH]|Pregnadienediols/therapeutic use[MESH]|Ranibizumab[MESH]|Treatment Outcome[MESH]|Triamcinolone Acetonide/therapeutic use[MESH] |