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lüll Interstitial and vascular type V collagen morphologic disorganization in usual interstitial pneumonia Parra ER; Teodoro WR; Velosa AP; de Oliveira CC; Yoshinari NH; Capelozzi VLJ Histochem Cytochem 2006[Dec]; 54 (12): 1315-25Recent evidence suggests that type V collagen plays a role in organizing collagen fibrils, thus maintaining fibril size and spatial organization uniform. In this study we sought to characterize the importance of type V collagen morphological disorganization and to study the relationship between type V collagen, active remodeling of the pulmonary vascular/parenchyma (fibroblastic foci), and other collagen types in usual interstitial pneumonia (UIP). We examined type V collagen and several other collagens in 24 open lung biopsies with histological pattern of UIP from patients with idiopathic pulmonary fibrosis (IPF). We used immunofluorescence, morphometry, and three-dimensional reconstruction to evaluate the amount of collagen V and its interaction with the active remodeling progression in UIP, as well as types I and III collagen fibers. Active remodeling progression was significantly related to type V collagen density (p<0.05), showing a gradual and direct increase to minimal, moderate, and severe fibrosis degree in UIP and in the three different areas: normal, intervening, and mural-organizing fibrosis in UIP. Parenchymal changes were characterized by morphological disorganization of fibrillar collagen with diverse disarray and thickness when observed by three-dimensional reconstruction. We concluded that in the different temporal stages of UIP, vascular/parenchyma collagen type V is increased, in disarray, and is the most important predictor of survival.|Biopsy[MESH]|Blood Vessels/chemistry/pathology[MESH]|Collagen Type I/analysis[MESH]|Collagen Type III/analysis[MESH]|Collagen Type V/*analysis[MESH]|Female[MESH]|Humans[MESH]|Lung Diseases, Interstitial/*pathology[MESH]|Lung/blood supply/chemistry/*pathology[MESH]|Male[MESH]|Microscopy, Confocal/methods[MESH]|Middle Aged[MESH]|Procollagen/*analysis[MESH]|Sensitivity and Specificity[MESH] |