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The inflammasome: first line of the immune response to cell stress Ogura Y; Sutterwala FS; Flavell RACell 2006[Aug]; 126 (4): 659-62The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.|*Oxidative Stress[MESH]|Adenosine Triphosphate/metabolism[MESH]|Animals[MESH]|Apoptosis Regulatory Proteins/genetics/metabolism[MESH]|CARD Signaling Adaptor Proteins[MESH]|Calcium Pyrophosphate/metabolism[MESH]|Calcium-Binding Proteins/genetics/metabolism[MESH]|Carrier Proteins/genetics/*metabolism[MESH]|Caspase 1/*metabolism[MESH]|Cytoskeletal Proteins/genetics/metabolism[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Immune System/*physiology[MESH]|Inflammation/*metabolism[MESH]|Interleukins/immunology[MESH]|NLR Family, Pyrin Domain-Containing 3 Protein[MESH]|Salmonella Infections/immunology[MESH]|Salmonella typhimurium/immunology[MESH]|Uric Acid/metabolism[MESH] |
