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Spinal dural arteriovenous fistulas: a congestive myelopathy that initially mimics a peripheral nerve disorder Jellema K; Tijssen CC; van Gijn JBrain 2006[Dec]; 129 (Pt 12): 3150-64Spinal dural arteriovenous fistula (SDAVF) is a rare and enigmatic disease entity. The clinical features and structural changes have been recognized since 1926, and the pathophysiology and the essentials of treatment since 1974, but up to the present day it is unknown why these fistulas develop. The fistula between a radicular artery and the corresponding radicular vein within the dural root sleeve leads to congestion of the venous outflow of the spinal cord and eventually ischaemia. Patients, who are mostly middle-aged men, develop a progressive myelopathy, which at the early stages of the disease often mimics a polyradiculopathy or anterior horn cell disorder. By the time involvement of upper motoneurons or sacral segments makes the diagnosis of SDAVF inescapable, patients suffer from considerable neurological deficits. The diagnosis relies on MRI, which shows swelling of the spinal cord, with a centrally located hyperintense signal on T2-weighted images, and with hypointense 'flow void' phenomena dorsal to the cord, representing enlarged and tortuous veins. Catheter angiography is required to determine the exact location of the fistula as well as the angio-architecture, on which the mode of treatment depends. If the arterial feeder of the fistula is a tributary of the anterior spinal artery, embolization is not possible. After embolization recanalization may occur, but this is rarely seen after filling of the draining vein with glue. Alternatively, operation is a safe and permanent mode of treatment. No prognostic factors have been reliably established. Muscle strength and gait disturbances respond better to treatment than pain and symptoms related to damage of sacral segments. In any middle aged male patient with ascending motor or sensory deficits in the legs, SDAVF should be considered in order to prevent irreversible handicap.|Central Nervous System Vascular Malformations/classification/*diagnosis/pathology/therapy[MESH]|Diagnosis, Differential[MESH]|Embolization, Therapeutic[MESH]|Female[MESH]|Humans[MESH]|Magnetic Resonance Angiography[MESH]|Male[MESH]|Peripheral Nervous System Diseases/*diagnosis[MESH]|Spinal Cord Diseases/classification/*diagnosis/pathology/therapy[MESH]|Spinal Cord/pathology[MESH]|Treatment Outcome[MESH] |
