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Regulatable gene expression systems for gene therapy Vilaboa N; Voellmy RCurr Gene Ther 2006[Aug]; 6 (4): 421-38It is feasible to restrict transgene expression to a tissue or region in need of therapy by using promoters that respond to focusable physical stimuli. The most extensively investigated promoters of this type are radiation-inducible promoters and heat shock protein gene promoters that can be activated by directed, transient heat. Temporal regulation of transgenes can be achieved by various two- or three-component gene switches that are triggered by an appropriate small molecule inducer. The most commonly considered gene switches that are reviewed herein are based on small molecule-responsive transactivators derived from bacterial tetracycline repressor, insect or mammalian steroid receptors, or mammalian FKBP12/FRAP. A new generation of gene switches combines a heat shock protein gene promoter and a small molecule-responsive gene switch and can provide for both spatial and temporal regulation of transgene activity.|*Gene Targeting[MESH]|*Genetic Therapy[MESH]|Animals[MESH]|Gene Expression Regulation/*physiology[MESH]|Humans[MESH] |
