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lüll Treating viral hepatitis C: efficacy, side effects, and complications Manns MP; Wedemeyer H; Cornberg MGut 2006[Sep]; 55 (9): 1350-9The treatment of hepatitis C has dramatically improved over the past decade. Unlike any other chronic viral infection, a significant proportion of patients with chronic hepatitis C can be cured. However, the current standard therapy--pegylated interferon alpha and ribavirin--has its limitations. Limited efficacy in patients with hepatitis C virus (HCV) genotype 1 and the side effect profile will necessitate the development of new therapeutic approaches. This review describes the efficacy and optimisation of the current standard therapy of hepatitis C and its problems in special patient populations. New treatment directions beyond interferon alpha based therapies are on the horizon.|Amantadine/therapeutic use[MESH]|Antiviral Agents/adverse effects/*therapeutic use[MESH]|Hepatitis C, Chronic/*drug therapy[MESH]|Humans[MESH]|Interferon-alpha/adverse effects/therapeutic use[MESH]|Ribavirin/adverse effects/therapeutic use[MESH]|Treatment Outcome[MESH] |