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lüll Churg-Strauss syndrome in children: a clinical and pathologic review Boyer D; Vargas SO; Slattery D; Rivera-Sanchez YM; Colin AAPediatrics 2006[Sep]; 118 (3): e914-20Churg-Strauss syndrome is a vasculitis accompanied by asthma and eosinophilia. It is generally considered a disease of adults; occurrence in children has been reported infrequently. Here we report 2 pediatric patients with Churg-Strauss syndrome manifesting with prominent pulmonary involvement. One, a 16-year-old with a previous history of asthma, presented with pleuritic chest pain and a peripheral pulmonary nodule complicated by an eosinophilic pleural effusion. The other patient presented at age 6 with cough, weight loss, and radiographic infiltrates. Lung biopsies revealed elements characteristic of Churg-Strauss syndrome, including eosinophilic microabscesses and vasculitis. Three- and 5-year follow-up showed continued symptoms in both patients despite medical therapy. Both patients illustrate many of the typical features of Churg-Strauss syndrome. We report these cases to expand the scant knowledge about Churg-Strauss syndrome in pediatric patients and to heighten awareness that this serious disease may affect the pediatric population. The relevant literature on Churg-Strauss syndrome, with specific reference to childhood cases, is reviewed.|Adolescent[MESH]|Chest Pain/etiology[MESH]|Child[MESH]|Churg-Strauss Syndrome/*complications/*pathology[MESH]|Cough/etiology[MESH]|Eosinophils[MESH]|Female[MESH]|Humans[MESH]|Lung Diseases/*etiology/pathology[MESH]|Necrosis[MESH]|Pleural Effusion/*etiology[MESH]|Weight Loss[MESH] |