Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells Yi H; Zhen Y; Jiang L; Zheng J; Zhao YCell Mol Immunol 2006[Jun]; 3 (3): 189-95The homeostasis of the immune system depends on the balance between the immune response to an invaded pathogen and the immune tolerance to self antigens. Both central and peripheral tolerances are important mechanisms for the induction and maintenance of T cell tolerance. Recently, much attention has been paid to regulatory T cells (Treg), which play a significant role in maintaining peripheral immune tolerance. So far, there has been no satisfactory advance regarding the surface markers of Treg cells, as none is unique for Treg cells. In this review, we summarize some important molecules expressed in naturally occurring CD4+CD25+ Treg cells (nTreg), including forkhead/winged-helix family transcriptional repressor p3 (Foxp3), the tumor necrosis factor receptor (TNFR) family, CD28/CTLA4 molecules, chemokine receptors, Toll-like receptors (TLRs), membrane-bound TGF-beta and other molecules, such as neuropilin-1, lymphocyte activation gene-3 (LAG)-3 and granzyme. This review provides a collective view on current studies of nTreg cell activation and development related to the expression of molecules and cell phenotype markers, which is important for elucidation of nTreg cell origin, development and function.|*Immune Tolerance[MESH]|Animals[MESH]|Antigens, Surface/*biosynthesis[MESH]|Humans[MESH]|Immunophenotyping[MESH]|Interleukin-2 Receptor alpha Subunit/*biosynthesis[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH]|Transforming Growth Factor beta/immunology[MESH] |