Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16891449&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pigment epithelium-derived factor: a multimodal tumor inhibitor Ek ET; Dass CR; Choong PFMol Cancer Ther 2006[Jul]; 5 (7): 1641-6Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has been known for years to be aberrantly expressed in ocular disorders, but in recent years, down-regulation has been shown to be prevalent in a range of cancers as well. This review describes the trimodal anticancer activities of this interesting protein: antiangiogenesis, apoptosis-mediated tumor suppression, and tumor cell differentiation. The key to successful antitumor therapy with this protein is the ability to synthesize the recombinant form of the protein (or its active shortened forms) and deliver at therapeutic doses or alternatively to use gene transfer technology to prolong the effect in vivo. Although there is a substantial amount of work carried out at the preclinical stage with this protein, more groundwork has to be done before PEDF is tested against cancer in clinical trials.|Angiogenesis Inhibitors/genetics/pharmacology/*therapeutic use[MESH]|Antineoplastic Agents/pharmacology/*therapeutic use[MESH]|Cell Differentiation/drug effects[MESH]|Eye Proteins/genetics/pharmacology/*therapeutic use[MESH]|Humans[MESH]|Neoplasms/blood supply/*drug therapy/pathology[MESH]|Nerve Growth Factors/genetics/pharmacology/*therapeutic use[MESH]|Serine Proteinase Inhibitors/genetics/pharmacology/*therapeutic use[MESH]|Serpins/genetics/pharmacology/*therapeutic use[MESH] |
