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lüll Review article: management of hepatic disease following haematopoietic cell transplant McDonald GBAliment Pharmacol Ther 2006[Aug]; 24 (3): 441-52Hepatic diseases are common complications of haematopoietic cell transplant. The causes are multiple: myeloablative conditioning regimens may cause sinusoidal injury; acute and chronic graft-versus-host disease lead to damaged hepatocytes and small bile ducts; microcrystalline deposits in the gall bladder can cause biliary symptoms; drug-induced liver injury is common; and the liver may be infected by viruses and fungi during the period of severe immune suppression that follows transplant. Pre-transplant evaluation and prevention of liver injury are often more useful than treatment of deeply jaundiced patients in improving transplant outcomes. This review covers pre-transplant evaluation, common hepatobiliary problems in the six months following transplant, and hepatic problems in long-term survivors.|Chronic Disease[MESH]|Graft vs Host Disease[MESH]|Hematopoietic Stem Cell Transplantation/*adverse effects[MESH]|Humans[MESH]|Liver Diseases/*etiology/prevention & control[MESH]|Virus Diseases/*etiology[MESH] |