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lüll The infectivity of transmissible spongiform encephalopathy agent at low doses: the importance of phospholipid Gale PJ Appl Microbiol 2006[Aug]; 101 (2): 261-74The issue of whether the mechanism of infection is independent or co-operative for low doses of transmissible spongiform encephalopathy (TSE) agent is critical for risk assessment. The susceptibility (and hence ID(50)) of individuals with the same prion protein (PrP) genotype may vary considerably with a small proportion being very susceptible. Assuming independent action, the incubation period (IP) would continue to increase until the dose is below the ID(50) of the most susceptible individuals in the experiment, at which point it would become constant. This may explain the observed increase in IP with decreasing dose below the apparent ID(50) in experiments with untreated TSE agent. In contrast, IPs for autoclaved or NaOH-treated TSE agent increase greatly at doses |Animals[MESH]|Brain/*metabolism[MESH]|Cattle[MESH]|Encephalopathy, Bovine Spongiform/metabolism/*transmission[MESH]|Environmental Exposure[MESH]|Genetic Predisposition to Disease[MESH]|Genotype[MESH]|Humans[MESH]|Mice[MESH]|Phospholipids/*metabolism[MESH]|PrPSc Proteins/*genetics/metabolism[MESH]|Risk Assessment/methods[MESH]|Statistics as Topic[MESH]|Toxicity Tests[MESH] |