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Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections Sauna ZE; Shukla S; Ambudkar SVMol Biosyst 2005[Jul]; 1 (2): 127-34Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.|Antifungal Agents/administration & dosage/chemistry/therapeutic use[MESH]|Antineoplastic Agents/administration & dosage/chemistry/therapeutic use[MESH]|Disulfiram/administration & dosage/chemistry/*therapeutic use[MESH]|Humans[MESH]|Models, Biological[MESH]|Molecular Structure[MESH]|Mycoses/*drug therapy[MESH]|Neoplasms/*drug therapy[MESH] |
