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  • The role of leptin in innate and adaptive immune responses
  • Bernotiene E; Palmer G; Gabay C
  • Arthritis Res Ther 2006[]; 8 (5): 217
  • Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Immune System/*physiology[MESH]
  • |Inflammation/*physiopathology[MESH]
  • |Leptin/*immunology[MESH]
  • |T-Lymphocytes/physiology[MESH]

  • *{{pmid16879738}}
    *<b>[ The role of leptin in innate and adaptive immune responses ]</b> Arthritis Res Ther 2006; 8(5) ; 217 Bernotiene E; Palmer G; Gabay C


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    Arthritis Res Ther

    217 5.8 2006