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lüll Prestin and the cochlear amplifier Dallos P; Zheng J; Cheatham MAJ Physiol 2006[Oct]; 576 (Pt 1): 37-42In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.|Animals[MESH]|Anion Transport Proteins/genetics/*physiology[MESH]|Cochlea/cytology/innervation/*physiology[MESH]|Deafness/genetics/physiopathology[MESH]|Hair Cells, Auditory, Outer/physiology[MESH]|Hearing/genetics/physiology[MESH]|Humans[MESH]|Mechanotransduction, Cellular/genetics/*physiology[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Molecular Motor Proteins[MESH]|Proteins/genetics/*physiology[MESH]|Sulfate Transporters[MESH] |