Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The fibroblastic coconspirator in cancer progression Egeblad M; Littlepage LE; Werb ZCold Spring Harb Symp Quant Biol 2005[]; 70 (ä): 383-8A remarkable change has occurred in the thinking about epithelial-derived cancer in recent years: From almost entirely focusing on oncogenes and tumor suppressor genes has come the realization that the tumor microenvironment is a coconspirator in the carcinogenic process. Many types of stromal cells, including fibroblasts, adipocytes, macrophages, mast cells, and cells of the vascular system, are crucial contributors to epithelial carcinogenesis. Here, we focus on the fibroblast's role in cancer progression and the molecules involved in the communications between the fibroblasts and the cancer cells, including fibroblast secreted protein 1 (FSP-1 or S100A4), transforming growth factor beta (TGF-beta), the chemokine CXCL-12 (stromal derived factor 1 alpha, SDF-1alpha), type I collagen, and matrix metalloproteinase 13 (MMP-13).|Animals[MESH]|Calcium-Binding Proteins/physiology[MESH]|Chemokine CXCL12[MESH]|Chemokines, CXC/physiology[MESH]|Collagen Type I/physiology[MESH]|Fibroblasts/*pathology/physiology[MESH]|Humans[MESH]|Matrix Metalloproteinases/physiology[MESH]|Models, Biological[MESH]|Neoplasms/*etiology/*pathology/physiopathology[MESH]|S100 Calcium-Binding Protein A4[MESH]|S100 Proteins[MESH]|Transforming Growth Factor beta/physiology[MESH] |