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Targeting XBP-1 as a novel anti-cancer strategy Koong AC; Chauhan V; Romero-Ramirez LCancer Biol Ther 2006[Jul]; 5 (7): 756-9The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.|DNA-Binding Proteins/*antagonists & inhibitors/genetics/*metabolism[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Humans[MESH]|Hypoxia/genetics/*metabolism[MESH]|Iron Regulatory Protein 1/metabolism[MESH]|Neoplasms/genetics/*metabolism/*therapy[MESH]|Protein Folding[MESH]|Regulatory Factor X Transcription Factors[MESH]|Transcription Factors/*antagonists & inhibitors/genetics/*metabolism[MESH]|Up-Regulation[MESH]|X-Box Binding Protein 1[MESH] |
