Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential Wangemann PJ Physiol 2006[Oct]; 576 (Pt 1): 11-21The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endocochlear potential and requires a highly specialized environment that enables and sustains sensory function. Disturbance of cochlear homeostasis is the cause of many forms of hearing loss including the most frequently occurring syndromic and non-syndromic forms of hereditary hearing loss, Pendred syndrome and Cx26-related deafness. The occurrence of these and other monogenetic disorders illustrates that cochlear fluid homeostasis and the generation of the endocochlear potential are poorly secured by functional redundancy. This review summarizes the most prominent aspects of cochlear fluid homeostasis. It covers cochlear fluid composition, the generation of the endocochlear potential, K(+) secretion and cycling and its regulation, the role of gap junctions, mechanisms of acid-base homeostasis, and Ca(2+) transport.|Acid-Base Equilibrium/physiology[MESH]|Animals[MESH]|Cochlea/cytology/innervation/*physiology[MESH]|Connexin 26[MESH]|Connexins[MESH]|Evoked Potentials, Auditory/*physiology[MESH]|Extracellular Fluid/*physiology[MESH]|Gap Junctions/physiology[MESH]|Hearing Loss/physiopathology[MESH]|Homeostasis/*physiology[MESH]|Humans[MESH]|Neurons, Afferent/physiology[MESH]|Potassium Channels/physiology[MESH]|Potassium/metabolism[MESH]|Signal Transduction/physiology[MESH]|Sodium-Potassium-Exchanging ATPase/physiology[MESH] |