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lüll Post traumatic epilepsy: a review of scientific evidence Gupta YK; Gupta MIndian J Physiol Pharmacol 2006[Jan]; 50 (1): 7-16Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy. The precise mechanisms of epileptogenesis in post-traumatic epilepsy are still poorly understood. Many structural, physiologic and biochemical changes in the brain may account for epileptogenesis. The reactive oxygen species (ROS), especially *OH and excitotoxicity are primarily involved. Antioxidants, like tocopherol, antiepileptic drug zonisamide, condensed tannins, melatonin, adenosine, trans-resveratrol, and some other agents have been proposed to prevent epileptogenic focus formation. The review also discusses various aspects of post traumatic epilepsy, mechanisms of epileptogenesis, and clinical implications.|*Brain Chemistry[MESH]|Animals[MESH]|Anticonvulsants/therapeutic use[MESH]|Antioxidants/therapeutic use[MESH]|Epilepsy, Post-Traumatic/drug therapy/*metabolism/pathology[MESH]|Humans[MESH]|Reactive Oxygen Species/*metabolism[MESH] |