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lüll Systematic review and meta-analysis: importance of CagA status for successful eradication of Helicobacter pylori infection Suzuki T; Matsuo K; Sawaki A; Ito H; Hirose K; Wakai K; Sato S; Nakamura T; Yamao K; Ueda R; Tajima KAliment Pharmacol Ther 2006[Jul]; 24 (2): 273-80BACKGROUND: Some, but not all studies have provided evidence that the CagA status of Helicobacter pylori strains is a predictive factor for the outcome of eradication therapy. AIM: To clarify the association between CagA status and eradication outcome. METHODS: We included studies reporting the numbers of successful and failed cases in H. pylori-eradication therapy according to the CagA status. Fourteen studies (1529 patients) were included of 325 articles identified in the search. The pooled risk ratio for H. pylori-eradication failure in CagA-negative relative to CagA-positive strains and the pooled risk difference in eradication success between the two groups were used as summary statistics. Meta-regression was used for examining the source of heterogeneity. RESULTS: The summary risk ratio for eradication failure in CagA-negative relative to CagA-positive was 2.0 (95% CI: 1.6-2.4, P < 0.001), corresponding with the summary risk difference for eradication success between the groups of 11% (95% CI: 3-19%, P = 0.011). Meta-regression analysis demonstrated that usage of polymerase chain reaction examination for CagA status and a high proportion of non-ulcer dyspepsia patients were factors for heterogeneity among studies. CONCLUSIONS: Our meta-analysis confirmed the importance of the presence of CagA as a predictor for successful eradication of H. pylori.|Antigens, Bacterial/*genetics[MESH]|Bacterial Proteins/*genetics[MESH]|Helicobacter Infections/*genetics/prevention & control[MESH]|Helicobacter pylori/*genetics[MESH]|Humans[MESH] |