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AMP-activated protein kinase signaling in metabolic regulation Long YC; Zierath JRJ Clin Invest 2006[Jul]; 116 (7): 1776-83AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming processes including glucose and lipid production to restore energy balance. AMPK controls whole-body glucose homeostasis by regulating metabolism in multiple peripheral tissues, such as skeletal muscle, liver, adipose tissues, and pancreatic beta cells--key tissues in the pathogenesis of type 2 diabetes. By responding to diverse hormonal signals including leptin and adiponectin, AMPK serves as an intertissue signal integrator among peripheral tissues, as well as the hypothalamus, in the control of whole-body energy balance.|*Energy Metabolism[MESH]|AMP-Activated Protein Kinases[MESH]|Glucose/metabolism[MESH]|Humans[MESH]|Isoenzymes/chemistry/metabolism[MESH]|Multienzyme Complexes/chemistry/*metabolism[MESH]|Muscle, Skeletal/metabolism[MESH]|Protein Serine-Threonine Kinases/chemistry/*metabolism[MESH]|Signal Transduction/*physiology[MESH] |
