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lüll CD1d ligands: the good, the bad, and the ugly Brutkiewicz RRJ Immunol 2006[Jul]; 177 (2): 769-75The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.|Adjuvants, Immunologic/metabolism/physiology[MESH]|Animals[MESH]|Antigen Presentation/*immunology[MESH]|Antigens, CD1/*immunology/*metabolism/physiology[MESH]|Antigens, CD1d[MESH]|Carbohydrate Sequence[MESH]|Humans[MESH]|Ligands[MESH]|Molecular Sequence Data[MESH]|Virus Diseases/immunology/virology[MESH] |