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Spike timing-dependent plasticity: from synapse to perception Dan Y; Poo MMPhysiol Rev 2006[Jul]; 86 (3): 1033-48Information in the nervous system may be carried by both the rate and timing of neuronal spikes. Recent findings of spike timing-dependent plasticity (STDP) have fueled the interest in the potential roles of spike timing in processing and storage of information in neural circuits. Induction of long-term potentiation (LTP) and long-term depression (LTD) in a variety of in vitro and in vivo systems has been shown to depend on the temporal order of pre- and postsynaptic spiking. Spike timing-dependent modification of neuronal excitability and dendritic integration was also observed. Such STDP at the synaptic and cellular level is likely to play important roles in activity-induced functional changes in neuronal receptive fields and human perception.|Action Potentials/*physiology[MESH]|Animals[MESH]|Brain/*physiology[MESH]|Humans[MESH]|Neuronal Plasticity/*physiology[MESH]|Perception/*physiology[MESH]|Synapses/*physiology[MESH] |
