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Retinoblastoma tumor suppressor: where cancer meets the cell cycle Knudsen ES; Knudsen KEExp Biol Med (Maywood) 2006[Jul]; 231 (7): 1271-81The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.|*Genes, Retinoblastoma[MESH]|Cell Cycle/*genetics[MESH]|Eye Neoplasms/*genetics/pathology[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Homeostasis[MESH]|Humans[MESH]|Retinoblastoma/*genetics/pathology[MESH] |
