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lüll Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology Tanabe K; Kon S; Natsume W; Torii T; Watanabe T; Satake MCancer Sci 2006[Sep]; 97 (9): 801-6The endocytosis of cell membrane proteins is initiated by the binding of activated Arf6, a member of Ras-related GTPases, to the PM. A GAP specific for Arf6 triggers the budding of endocytotic vesicles from the PM by inactivating GTP-bound Arf6. We recently identified the SMAP gene that encodes an ArfGAP and is involved in the endocytosis of TfnR and possibly E-cadherin. In this review, we summarize the process of intracellular membrane trafficking, highlighting the roles played by the SMAP gene. Progression of cancer to malignancy occurs in parallel with the disappearance of E-cadherin, a central component of the adherens junction in epithelial cells. Therefore, elucidation of the molecular mechanism of E-cadherin endocytosis should be one of the key elements in tumor cell biology.|Adaptor Proteins, Signal Transducing/genetics/*metabolism[MESH]|Animals[MESH]|Cadherins/metabolism[MESH]|Cell Membrane/*metabolism[MESH]|Cell Transformation, Neoplastic/*metabolism[MESH]|Cytoskeletal Proteins/genetics/*metabolism[MESH]|Endocytosis/physiology[MESH]|Humans[MESH]|Protein Transport/*physiology[MESH]|Receptors, Transferrin/metabolism[MESH]|Signal Transduction/*physiology[MESH] |