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Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy Holaska JM; Wilson KLAnat Rec A Discov Mol Cell Evol Biol 2006[Jul]; 288 (7): 676-80X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.|Animals[MESH]|Cell Nucleus/*chemistry/metabolism/*physiology[MESH]|Humans[MESH]|Membrane Proteins/*physiology[MESH]|Muscular Dystrophy, Emery-Dreifuss/*genetics/*metabolism/pathology/physiopathology[MESH]|Nuclear Proteins/*physiology[MESH]|Organ Specificity/genetics[MESH] |
